Integrated by Design
A modular approach allows customers to select standard process modules to suit specific project needs: fully integrated turnkey installations can be supplied, including fluid bed process equipment combined with top- and bottom-drive high shear mixer-granulators with integrated contained materials handling, wet and dry milling facilities, product handling systems, binder and coating preparation units, filtration units and tablet compression machines.
Safety, containment, product flow and building requirements are in-built for full integration and optimum process efficiency. Our service includes design, installation assistance, commissioning and process validation, as well as training and technical support. Installation, operation qualification and documentation are done according to FDA/GAMP guidelines.
Controlling Your Process
Advanced PLC-based automation provides seamless integration of process and CIP control functions. Options include a graphical MMI operator interface, online monitoring and trending, recipe handling, batch management, barcoding and full CIM integration. Industry standard communication networks ensure full compatibility with existing control strategies and plant-wide supervisory systems.
Process Analytical Technology
The FDA’s PAT (Process Analytical Technology) initiative has enabled GEA to combine its equipment design skills and process engineering know-how to integrate online (PAT) analyzers into its systems in a way that can provide real insight into the operation of the process and help customers to achieve key product quality targets.
The goal of the PAT initiative is to ensure that pharmaceutical products are manufactured using processes that are understood and monitored so that the key quality characteristics of the products can be actively controlled.
Containment
Our distinctive specialization lies in the integration of the BUCK® containment technology into complete solutions for pharmaceutical solid dosage form facilities. With an emphasis on quality and GMP standards, we are committed to working together with our customers to deliver custom-built, first class solutions for projects of all sizes and complexity.
Safety and the Environment
For full compliance with national, local and in-house regulations, GEA offers a range of emission control options including solvent recovery systems, outlet filters and full containment plants. Equipment can be supplied to meet explosion-proof and pressure shock standards as required.
Cleaning and Maintenance
Process optimisation depends on efficient, effective cleaning. Automation of the cleaning process ensures repeatability, allows validation and minimizes downtime. In recognition of the fundamental role played in today’s advanced powder processing industry by automated clean-in-place procedures, GEA has developed a unique approach to CIP.
Concealed services: The integrated design ensures that all lines and hoses for the utilities of the plant (water, electricity, hydraulics, etc.) are concealed. This creates a safe and uncluttered working space.
CIP and WIP systems: More efficient cleaning is one of the key advantages of system integration. We provide validated cleaning with minimal downtime. GEA offers CIP-by-design (patented) features into all of its process. Every aspect of the integrated plant, from inlet to discharge, has been value-engineered for optimum cleanability. Spray system, tanks cleaners, nozzles and seals are an integral part of our equipment design. Every plant delivered by GEA has a tailor made WIP or CIP system that suits your process.
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Verwandte Produkte
Wirbelschichtverarbeitung von Arzneimitteln
GEA liefert Wirbelschichtprozessoren (in den USA als Multi-Prozessor™ bekannt) für das Mischen, die Granulation, die Trocknung, die Pelletisierung und die Beschichtung in der pharmazeutischen Industrie.
Gral High Shear Granulators
Whether the customer’s requirement is for high shear mixing or granulation, GEA has a solution for every processing challenge and can help select the technology that is most suitable for your Pharma application.
PMA High Shear Processor
PMA Bottom-drive High Shear Granulators suitable for the high speed dispersion of dry powders, aqueous or solvent granulations, effervescent production and melt pelletization for Pharmaceutical applications.
Lighthouse Probe® - online measurement
The Lighthouse Probe® can be used for real-time monitoring of chemical and pharmaceutical processes and provides in-process window cleaning at any time, recalibration during the process, full CIP (cleaning) of wash housing and seal, and a clear view inside – even in difficult conditions.
GEA Insights
Der Durchbruch, der die Sprühtrocknung revolutionierte
Im Jahr 1976 stellten sich die Ingenieure von NIRO einer neuen Herausforderung im Wettbewerbsumfeld und überdachten die Möglichkeiten der Sprühtrocknung. Aus ihrer Idee entstand der Mehrstufentrockner MSD. Fünfzig Jahre später trägt dasselbe Grundprinzip dazu bei, Flüssigkeiten in Pulver umzuwandeln, die weltweit in unverzichtbaren Ernährungsprodukten und wichtigen Arzneimitteln zum Einsatz kommen. Der MSD wurde durch jahrzehntelanges ingenieurtechnisches Know-how, Kundenfeedback und kontinuierliche Weiterentwicklung verfeinert und steht für eine Erfolgsgeschichte der Innovation mit nachhaltiger Wirkung.
Das Ganze im Blick: Wie Anlagen dauerhaft besser laufen
Eine effiziente Maschine macht noch keine effiziente Produktion. Echte Verbesserungen beginnen oft damit, den Blick über die einzelnen Anlagenelemente hinaus zu richten und zu verstehen, wie sich Prozesse, Energiesysteme und betriebliche Entscheidungen gegenseitig beeinflussen. Ein solcher ganzheitlicher Ansatz hilft beim Identifizieren von Potenzialen, die sonst verborgen bleiben.
Wie eine neue Ventiltechnologie die Produktion von Lebensmitteln und Getränken verändert
In der Lebensmittel- und Getränkeindustrie werden Ventile traditionell mit Druckluft betrieben. Die GEA Hydract®-Antriebstechnologie betätigt Ventile dagegen mit Wasser in einem geschlossenen, digital gesteuerten Kreislauf. Das Ergebnis: Ventile lassen sich präzise in jeder gewünschten Position halten und in fein abgestuften Schritten steuern. Dadurch sinken der Energieverbrauch und gleichzeitig steigt die Prozesskontrolle erheblich.
