Liquid Dosage
Animal cell cultures
Cell culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. Cell cultures can be initiated from normal, embryonic or malignant tissue by aseptic collection from the animal host. In some cases, physical or enzymatic methods are used to disrupt the cells to prepare suspensions of single cells.
Animal cell culture technology has advanced significantly during the last few decades and is now generally considered to be a reliable, robust and relatively mature technology. A range of biotherapeutics is currently synthesized using cell culture methods in large-scale manufacturing facilities that produce products for both commercial use and clinical studies.
Using mammalian cell cultures, proteins can be produced in their effective form (quarternary structure). And, compared with microbial production in bacteria and yeasts, downstream processing is significantly reduced. In addition, infection risks in the production of human proteins can be avoided.
The robust implementation of mammalian cell technology requires a number of key variables to be optimized, including the culture media and bioreactor conditions, appropriate cell lines (CHO, BHK, hybrid and insect cells), low operating costs, high productivity rates, efficient process control and, above all, quality.
Successful implementation also requires appropriate strategies for process development, scale-up and characterization, and the validation of robust procedures that comply with current regulations.
Optimized Separation Processes
Particular attention must be paid to the effects of external influences such as shear forces on the behavior and productivity of the cells. The hydrohermetic inlet developed by GEA reduces shear forces to a minimum, an innovation that has been tested and published in co-operation with the University of Bielefeld (Germany).
As a competent manufacturer of complete plant for the life science industries, GEA is a full-service provider of solutions that meet your exact requirements and specifications. From planning, development and installation to qualification and maintenance, our experienced engineers will collaborate with your project team to supply innovative and efficient process solutions for your cell culture applications.
Productos y tecnologías
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Hygienic pumps
GEA Hilge ofrece una gama versátil de bombas centrífugas y de desplazamiento positivo para una amplia variedad de aplicaciones sensibles en las industrias de bebidas, alimentaria y farmacéutica.
Lyophilizers (Pharma Freeze Dryers)
GEA's thorough understanding of the lyophilization process enables them to supply a comprehensive range of products and services, comprising laboratory equipment, pilot plants for research and small-scale production batches, industrial size pharmaceutical production freeze dryers.
Separador centrífugo
Los separadores de GEA están diseñados para aplicaciones a base de líquidos. Utilizan fuerza centrífuga y se emplean para separar suspensiones que consisten de dos o más fases de distinta densidad; por ejemplo, pueden separar líquido-líquido, líquido-líquido-sólido o líquido-sólido. También son eficaces para separar mezclas líquidas a la vez que ...
Sistemas de carga y descarga
El diseño, el desarrollo y la fabricación de sistemas de carga y descarga para aplicaciones de varias industrias es una de las principales actividades de GEA. Para cualquier producto o proceso se pueden crear y suministrar soluciones a medida o convencionales, ya sean manuales o automáticas, que satisfagan las necesidades concretas de los cliente...
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GEA Insights
GEA NEXUS: Una solución integral para un procesado de alimentos más sostenible
El cambio climático y el aumento de la población mundial ejercen una presión cada vez mayor sobre la industria alimentaria, que consume mucha energía, para alimentar a más personas sin afectar aún más al planeta. George Shepherd, Global Technical Sustainability Manager de GEA, explica cómo GEA utiliza sus conocimientos de ingeniería para ayudar a los procesadores a producir de forma más sostenible y, al mismo tiempo, aumentar la productividad.
Making milk production more sustainable for a growing world
The world's population is growing and with it demand for milk. Dairy is an essential component of many global diets. However, its production can be resource-intensive and impact the environment. GEA’s Christian Müller, Senior Director Sustainability Farm Technologies, sheds light on how technological innovations powered by GEA make milk production more efficient and profitable.
Máquinas limpias, alimentos seguros: El poder del diseño higiénico
Cada bebida y cada bocado de comida seguro es una victoria contra amenazas microbianas invisibles, una batalla moldeada por un siglo de diseño de procesos higiénicos. Con más de 100 años de experiencia en ingeniería y diseño higiénico, GEA marca la pauta en la industria de equipos de procesado que protegen los alimentos y salvan vidas.
