Pharmaceutical R&D Technology: Granulation, Blending, Drying, Milling & Pelletizing
At the heart of GEA's small-scale and R&D approach is PharmaConnect®, which allows a number of diverse process modules to be docked to a single control unit.
Based on GEA's market-leading granulation technologies and designed for laboratory through to pilot plant scale, the PharmaConnect® can process batches from 200 g to 25 kg or more, all from a single control unit.
The PharmaConnect® is not just limited to granulation; its unique design allows any number of process technologies to be operated from the single operator interface, including
Two versions of the control unit are available: a through-the-wall option and a mobile module. The unit also features a touchscreen user interface, a module drive motor and GEA’s Module Recognition System (MRS), which automatically detects the type and capacity of the connected module, seamlessly displaying an image of the process on-screen and both enabling and defining the correct operational set points and parameters.
PharmaConnect® is true PAT-compatible, cGMP-compliant, plug-and-play solution for the busy formulation scientist.
Equipment Size | Typical Minimum Batch @ 0.6sg | Typical Maximum Batch @ 0.6sg |
1 | 240 g | 450 g |
3 | 720 g | 1.35 g |
5 | 1.2 kg | 2.25 kg |
Equipment Size | Typical Minimum Batch @ 0.6sg | Typical Maximum Batch @ 0.6sg |
10 | 2.4 kg | 4.5 kg |
15 | 3.6 kg | 6.75 kg |
Equipment Size | Typical Minimum Batch @ 0.6sg | Typical Maximum Batch @ 0.6sg |
20 | 4.8 kg | 9 kg |
30 | 7.2 kg | 13.5 kg |
60 | 14.4 kg | 27 kg |
For more than 40 years, Turbo Rapid machines have delivered high intensity blending solutions for dry powders. The unique, high speed TRV impeller blades provide the homogeneity and stability that are key factors in the production of inhalable drugs.
Available with working capacities from 150 g up to 30 kg, the TRV is available as a standalone or PharmaConnect® options.
Penn Pharma High Containment Facility
A range of standard bowl sizes are available to handle batch quantities of
1-3 L for development scale (the optimal choice for recipe and process development using very small quantities of active material); 5, 10 and 15 L (an intermediate scale for continued product development; and 30 and 60 L for pilot-scale production. However, the modular format of PharmaConnect® allows special modules to be used for customer-specific needs, such as non-standard capacities, different shapes or even different materials such as glass.
Offering a wide range of processing capacities, standard module sizes for the bottom-driven PMA are set at 1, 3, 5, 10, 15, 20, 30 and 60 L, with each unit being geometrically scalable. Critically, each of these modules features its own impeller drive motor, maintaining a consistent energy input per unit volume and enabling true scale-up data to be generated, even at the 1 L level, for commercial expansion.
The state-of-the-art Gral top driven granulation system is renowned worldwide for its high quality, robust design and scalability. The Gral module for PharmaConnect® has a bowl size of 60 L. Furthermore, integration with the PharmaConnect® control unit provides complete process flexibility.
Designed specifically as a pelletization system for the pharmaceutical industry and able to pelletize small batches (50 g) using the operating principles of larger pilot-scale and production machines, the NICA IPS-5 extruder and spheronizer is the perfect development partner for the PharmaConnect®.
The NICA IPS5 operates exclusively as a process module on the GEA PharmaConnect® platform, combining the NICA E100 basket extruder with the NICA S250 spheronizer.
Ons kleinschalige assortiment, een breed scala aan R&D-technologieën ontworpen voor specifieke toepassingen, beslaat alle aspecten van de productie van vaste orale toedieningsvormen (OSD), van high-shear mixers, wervelbeddrogers en éénpotsystemen tot extrusiemachines en sferonisators, mengers en containmentoplossingen tot tabletcompressie.
PMA Bottom-drive High Shear Granulators suitable for the high speed dispersion of dry powders, aqueous or solvent granulations, effervescent production and melt pelletization for Pharmaceutical applications.
Whether the customer’s requirement is for high shear mixing or granulation, GEA has a solution for every processing challenge and can help select the technology that is most suitable for your Pharma application.
FlexStream™ is een nieuwe multifunctionele processor die een einde maakt aan de huidige tekortkomingen van traditionele wervelbedden, met betrekking tot bijv. lineaire schaalvergroting en volledig gesloten laden en lossen voor farmaceutische toepassingen.
Afvalreductie is belangrijk voor ons bij GEA en door de kracht van vriesdroogtechnologie te benutten, kunnen we voedseloverschotten omzetten in waardevolle, duurzame producten die ons helpen afval te reduceren, de houdbaarheid te verlengen en een beter bestendige voedselvoorzieningsketen voor toekomstige generaties te creëren.
Toen de Zuid-Koreaanse ‘plant-forward’ voedselproducent Pulmuone bij GEA aanklopte met de uitdaging om een moderne draai aan de traditionele taaie koude (naengmyeon-) noodle te geven, konden de R&D-experts van GEA de uitdaging aan. Ze hielpen met de ontwikkeling van wat nu een commerciële hit is die met minder water en elektriciteit wordt geproduceerd dan de reeds bestaande methoden. Het resultaat is ook getrouw aan de traditionele oorsprong van het gerecht, evenals de wortels van Pulmuone op het gebied van gezondheid, welzijn en duurzaamheid.