Experience, Expertise and Know-How

• Granulation is often required to improve the flow of powder and mechanical properties of tablets
• Granules are usually obtained by adding liquids binder or solvent solutions
• Larger quantities of granulating liquid produce a narrower particle size range and coarser and harder granules; that is, the proportion of fine granulate particles decreases
• The optimal quantity of liquid needed to get a given particle size should be known to keep batch-to-batch variations to a minimum.
• Wet granulation is used to improve flow, compressibility, bioavailability, homogeneity, electrostatic properties and the stability of solid dosage forms
• The particle size of a granulate is determined by the quantity and feeding rate of the granulating liquid
• Granulation involves smaller particles adhering to each other to produce larger particles or agglomerates
• Particle size is critical: too large or too small, the particles will not produce high density, free-flowing granulates
• There are many variables in controlling a granulator process, ranging from feed rate of the granulator liquid to the resonance time of the granulator chamber, all of which affect the particle size in different ways
• With an online sensor, the particle size is measured instantaneously and continuously in real-time helping to monitor and control the granulation process.