Solid Dosage
CNS medication
We supply proven solutions for manufacturing central nervous system drugs, tackling challenges such as containment, intranasal delivery, small-scale R&D, etc
Manufacturing CNS Medication
There are many different types of drugs that work on the central nervous system (CNS), including anesthetics, anticonvulsants, antiemetics, anti-Parkinson agents, stimulants, muscle relaxants and sedatives.
As many of these products can cause serious side-effects from occupational exposure, containment is a key aspect to consider during the manufacturing process. As containment experts, we not only offer the largest variety of solutions for contained processing, but also unrivaled experience in identifying the most appropriate solution based on a containment risk analysis.
Delivering medication to the central nervous system remains challenging, which is why the industry continues to look at alternative methods of administration, such as the intranasal route or the use of colloidal drug carriers.
For inhalable versions, homogeneity and stability are key factors. Our dry powder blending, spray drying and particle engineering capabilities ensure that the production of free-flowing, aerodynamic particles at the correct size is achievable at the scale you need.
We also supply proven solutions for solid dispersions for bioavailability enhancement, such as extrusion, spheronization and a complete engineering service from system design to process integration and optimization.
Furthermore, we understand that during early research and development (R&D), the availability of the active ingredient is often limited. As such, there is an absolute requirement for process equipment that is capable of producing just a few hundred grams of finished product to fast-track new drug formulations.
Designed for small-scale and R&D applications, particularly with potent actives, the PharmaConnect®-PLUS — based on the established combination of a single control unit with a diverse range of process modules — is GEA’s modular granulation, extrusion/spheronization and blending system that offers an unbeatable range of process types and capacities, and also integrates with the Flexstream range of fluidized bed processors.
In addition, the ConsiGma® 4.0 platform combines Quality by Design (QbD) principles with DoE to explore and optimize a wide range of process parameters with less product in a shorter time frame.
Products & Technologies
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Analytical, in-line control & measurement devices
Combining process monitoring using online analyzers, together with solid process engineering principles and advanced process modelling techniques will enable processes to be actively controlled in order to compensate for input variations.
CIP/SIP Solutions
Innovative CIP concepts of GEA meet comprehensive high standards. Our experts guarantee product safety at every point of the process. Every upgrade is adapted to individual local conditions and customer requirements and leads to noticeable savings.
Contained Materials Handling Systems
Contained Materials Handling solutions for Primary and Secondary Pharmaceuticals and Healthcare. With extensive experience within the generics sector, supply a wide range of technologies and equipment that improve and enhance the efficiency and performance of Oral Solid Dosage production.
Continuous Direct Compression Line
The ConsiGma® DC for direct compression is the latest expansion of GEA's continuous portfolio for cost effective, compact, high yield manufacturing systems. It offers a robust and flexible manufacturing method for a wide range of products.
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