Manufacturing CNS Medication
There are many different types of drugs that work on the central nervous system (CNS), including anesthetics, anticonvulsants, antiemetics, anti-Parkinson agents, stimulants, muscle relaxants and sedatives.
As many of these products can cause serious side-effects from occupational exposure, containment is a key aspect to consider during the manufacturing process. As containment experts, we not only offer the largest variety of solutions for contained processing, but also unrivaled experience in identifying the most appropriate solution based on a containment risk analysis.
Delivering medication to the central nervous system remains challenging, which is why the industry continues to look at alternative methods of administration, such as the intranasal route or the use of colloidal drug carriers.
For inhalable versions, homogeneity and stability are key factors. Our dry powder blending, spray drying and particle engineering capabilities ensure that the production of free-flowing, aerodynamic particles at the correct size is achievable at the scale you need.
We also supply proven solutions for solid dispersions for bioavailability enhancement, such as extrusion, spheronization and a complete engineering service from system design to process integration and optimization.
Furthermore, we understand that during early research and development (R&D), the availability of the active ingredient is often limited. As such, there is an absolute requirement for process equipment that is capable of producing just a few hundred grams of finished product to fast-track new drug formulations.
Designed for small-scale and R&D applications, particularly with potent actives, the PharmaConnect®-PLUS — based on the established combination of a single control unit with a diverse range of process modules — is GEA’s modular granulation, extrusion/spheronization and blending system that offers an unbeatable range of process types and capacities, and also integrates with the Flexstream range of fluidized bed processors.
In addition, the ConsiGma® 4.0 platform combines Quality by Design (QbD) principles with DoE to explore and optimize a wide range of process parameters with less product in a shorter time frame.
Produits et technologies
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Automatisation des procédés
En tant qu’intégrateurs de systèmes, nous associons notre savoir faire en matière de technologie de process et d'engineering aux logiciels de contrôle commande et de supervision développés par des leaders du marché.
Contained Materials Handling Systems
Contained Materials Handling solutions for Primary and Secondary Pharmaceuticals and Healthcare. With extensive experience within the generics sector, supply a wide range of technologies and equipment that improve and enhance the efficiency and performance of Oral Solid Dosage production.
Continuous Direct Compression Line
The ConsiGma® DC for direct compression is the latest expansion of GEA's continuous portfolio for cost effective, compact, high yield manufacturing systems. It offers a robust and flexible manufacturing method for a wide range of products.
Continuous Granulation Lines
Continuous Processing is becoming more and more important in the pharmaceutical industry. GEA takes the lead in introducing this innovative technology with ConsiGma® - continuous high-shear granulation and drying lines.
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GEA Insights
The breakthrough that changed spray drying
In 1976, NIRO engineers responded to a competitive challenge by rethinking what spray drying could do. Their idea became the multi-stage dryer MSD. Fifty years later, the same fundamental principle helps turn liquids into the powders used in essential nutrition products and important medicines around the world. Refined through decades of engineering expertise, customer insight and continuous development, MSD is a story of innovation with lasting impact.
Au-delà des machines : exploiter les gisements de performance des installations
Ce n'est pas parce que vous avez des machines efficaces que votre usine l'est. Une trajectoire d'amélioration efficace commence souvent par une analyse qui ne se limite pas aux équipements pris individuellement, et cherche à comprendre comment les processus, les systèmes énergétiques et les décisions opérationnelles s'influencent mutuellement. C'est une démarche holistique, conçue pour repérer des opportunités qui, sans cela, risqueraient de passer inaperçues.
Comment une vanne révolutionne la production des aliments et des boissons
Dans les installations agroalimentaires, les vannes sont généralement actionnées en utilisant de l'air comprimé. La technologie d'actionnement GEA Hydract® Actuation Technology, quant à elle, actionne les vannes en utilisant de l'eau, au sein d'un circuit fermé à commande numérique. Résultat, une vanne peut être maintenue en place de manière exacte et réglée par petits paliers. Cela se traduit par une consommation d'énergie en baisse et un meilleur contrôle.
