Liquid Dosage
Liposomes
As a drug delivery system, liposomes offer significant therapeutic benefits in terms of active ingredient targeting and controlled release. Hydrophobic moieties can be dissolved into the liposome membrane — a lipid bilayer — and, as such, they can be used to carry both hydrophobic and hydrophilic molecules.
To deliver molecules to sites of action, the liposome binds and fuses with other bilayers, such as a cell membrane, thus delivering its contents. By making liposomes in a drug solution (which would not normally be able to penetrate the membrane), they can be (indiscriminately) delivered through the lipid bilayer into the cell interior.
High-pressure homogenization is an ideal liposome production method, offering excellent results in terms of reduced vesicle diameters. Further, a wide range of different sizes and distributions can be achieved by altering the applied pressure and the number of passes through the homogenizer.
A wide range of products, including liposomes, can be freeze dried to retain their original properties. By adding water or other solvents, they can be reconstituted easily and very quickly to a usable solution. There is no need for cooling during storage, which is both cost-effective and makes handling easier.
GEA specializes in the design and manufacture of freeze dryers for the pharmaceutical and biotech industries and has an in-depth knowledge of lyophilization technology.
Products & Technologies
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Analytical, in-line control & measurement devices
Combining process monitoring using online analyzers, together with solid process engineering principles and advanced process modelling techniques will enable processes to be actively controlled in order to compensate for input variations.
Aseptic Pigging System
An aseptic pigging system allows to recover cost intensive products out of product lines. Powered by compressed sterile air, the pig pushes the product out of the pipe. The remaining product film on the inside of the product line can then be removed with the CIP.
Aseptic valves & components
Aseptic valves face exceptionally high demands within UltraClean and Aseptic processes. You can be assured that they all provide highest quality in terms of hygienic design and sustainability.
Back-pressure Valves
Aseptic back-pressure valves are used to regulate a pre-defined pressure in UltraClean and Aseptic processing plants.
