ConsiGma®
ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines
A highly integrated solution for continuous linear blending and direct compression, the ConsiGma® DC-LB lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled blending and compression and improved quality.
Continuous Direct Compression
Available in 2 standard sizes, depending on the desired throughput (from 1 to 100 kg/h or 20,000 to 150,000 tablets/h to be verified by testing), the systems can be customized with a number of options to suit customer needs.
The Conductor 4.0 software ensures seamless control of the entire process and provides full reporting and track & trace.
Mainly targeted towards high-value products (low dose API), orphan drugs and new chemical entities, and particularly suited for challenging recipes that require two-stage blending or more dispersive blending, the systems can be equipped with cleaning and containment features to handle highly potent formulations.
Standard Configuration
Up to 6 loss-in-weight feeders with automatic top-up systems
2 linear blenders
GEA compression system
Available Options
PAT tools
Hot swap parts for fast changeover
Material handling system including containment features
Containment upgrade
Coater
Main Benefits
Reduced risk of segregation – no material hold-ups
Highest possible blend homogeneity – all powder particles go through the same mixing event
Higher material yield
High flexibility from very low to very high API content
In process blend uniformity control – second-by-second
Adaption to variable throughput capacities
No hold-up issues
Wider drug load range than batch processing
System automatically adapts to changes in bulk density
Adaptable top-up sizes to ensure accurate feeding
Automatically adjustable dwell time
Flexible batch size
Smaller footprint
Read more about how GEA and its partners are implementing this technology to lead the way toward smaller, more flexible, continuous processing technologies that are transforming the future of pharmaceutical development and manufacturing.
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Aanverwante producten
ConsiGma® Granulation and Compression (GC) Lines
Highly integrated solutions for continuous wet granulation, drying and tablet compression, the ConsiGma® GC lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled granulation and improved quality.
ConsiGma® Tablet Coating (TC) Modules
The ConsiGma® TC modules are based on the GEA high-performance tablet coating technology that gently and accurately deposits controlled amounts of coating materials onto tablet cores — even if they are hygroscopic or friable.
ConsiGma® R&D Granulation and Drying (GD)
The ConsiGma® GD 25/80 offers standalone continuous twin-screw granulation and drying for small-scale R&D operations. It allows users to develop the process and achieve high granule quality on a compact unit.
Lighthouse Probe® - online measurement
The Lighthouse Probe® can be used for real-time monitoring of chemical and pharmaceutical processes and provides in-process window cleaning at any time, recalibration during the process, full CIP (cleaning) of wash housing and seal, and a clear view inside – even in difficult conditions.
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