Liquid Dosage
Insulin
With diabetes on the rise and the global insulin market estimated to be worth more than $32 billion by 2018, demand for GEA technologies for the production of this life-saving drug is already high and set to increase, particularly in new markets and emerging economies.
State-of-the-Art Solutions
GEA produces and supplies process systems for the production of liquid products for the pharmaceutical and biotechnological industries, and has a proven history of successfully installing plant for the production of insulin, including the engineering, delivery, commissioning and qualification of entire ultra-pure media systems as well as various process equipment and cleaning installations.
A worldwide technology leader in insulin production, GEA is able to supply the clean utility systems and manage the integration of all the main processes, including fermentation, harvesting, chromatography, filtration and freeze drying.
From Fermentation to Freeze Drying
The biosynthetic production of human insulin is done using bacteria or yeast cells. Following fermentation, or the conversion of chemical raw materials by micro-organisms, the biomass is extracted using a nozzle separator, washed, concentrated and finally precipitated to produce insulin crystals.
Centrifuges and process lines provided by GEA have an established pedigree in the clarification, separation, classification, concentration and fractionation steps. Nozzle separators also play an important part in the production process. Further, GEA chamber or self-cleaning separators can be used in the subsequent crystallization stages.
GEA is a single-source supplier of a variety of fermenters, media preparation, buffer storage, harvesting and cell rupture solutions, equipment for the purification and isolation of cells, separation (after both first and final crystallization), the production and distribution of WFI, CIP and freeze drying technologies, all of which can be installed and integrated into a state-of-the-art insulin production facility.
Produits et technologies
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Bloc de compression pour homogénéisateur
Les têtes de compression de GEA constituent le cœur des homogénéisateurs, car elles activent le processus d'homogénéisation en pompant le produit à haute pression jusqu'à ce qu'il s'écoule dans la vanne d'homogénéisation.
Bol séparateur à chambre
Les centrifugeuses à chambre sont utilisées pour les liquides de polissage de l'industrie chimique et pharmaceutique, en particulier lorsque qu'il s'agit de récupérer les liquides clarifiés, mais aussi les solides, et que ces derniers doivent former des produits secs.
Clarificateur
Le séparateur centrifuge de clarification est utilisé pour séparer les solides contenus dans un liquide. Le séparateur est équipé d'une colonne de disques coniques qui créent une grande zone de clarification équivalente dans une chambre de taille relativement petite.
Dispositifs d'analyse, de régulation en ligne et de mesure
Associer la surveillance du procédé grâce à des analyseurs en ligne aux principes d'ingénierie de procédé et aux techniques avancées de modélisation du procédé permet de contrôler activement le procédé et de pouvoir compenser les variations de l'alimentation.
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