Liquid Dosage
Hormones & Steroids
Steroids, endogenous hormones such as the sex hormones estrogen and testosterone or the hormones of the adrenal cortex, cortisol and aldosterone, play a key role in metabolic processes and have a number of pharmaceutical applications, including hormone therapy, anti-rheumatic, anti-arthritic and bodybuilding preparations.
Mainly used in the global hormone replacement therapy, currently worth about $3.6 billion, the three major segments comprise estrogen, growth and thyroid hormone, and testosterone replacement therapy. A major market driver is the increased awareness of postmenopausal hazards amongst women; others include an ageing population, innovative drug delivery systems and the pharmerging economies.
Predominantly based on cholesterol, steroid hormones are synthesized in the endocrine glands and transported to target tissue by the blood. At their site of action, they dock with highly specific cellular receptors and perform a key function in protein formation. To produce steroid hormones for pharmaceutical applications outside the body, a direct extraction procedure from special nutrient solutions is used.
Counter-Current Liquid-Liquid Extraction
In continuous direct extraction from GEA, the fermented nutrient solution is treated by liquid-liquid extraction in a counter-current process. Following precipitation, concentration, crystallization and drying of the extract, the steroid hormones are available in the form of a raw salt and can be correspondingly processed by the pharmaceutical industry. In a continuous direct extraction process, the fermented nutrient solution undergoes a counter-current liquid-liquid extraction process (also known as also known as solvent extraction or partitioning). Following precipitation, concentration, crystallization and drying, the extracted steroid hormones are available in the form of a raw salt and can be subsequently processed by the pharmaceutical industry.
Fromfacility design and layout, manufacturing process controls (including adherence to standard operating procedures) and environmental control systems (HVAC) to extraction systems, industrial hygiene solutions and fully integrated, end-to-end containment solutions, GEA has the experience and know-how to implement and optimize end-to-end production lines for steroid- and hormone-based applications.
Producten & technologieën
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Centrifugaalseparator
Separatoren van GEA zijn ontworpen voor toepassingen met vloeistof. Met behulp van centrifugaalkracht kunnen ze worden gebruikt voor het scheiden van suspensies die twee of meer fasen met verschillende dichtheden bevatten; dat wil zeggen dat ze gebruikt kunnen worden voor vloeistof-vloeistof-scheiding, vloeistof-vloeistof-vastestof-scheiding of v...
CIP/SIP-oplossingen
Innovatieve CIP-concepten van GEA voldoen aan hoge normeringen. Onze experts garanderen productveiligheid in elke fase van het proces. Elke upgrade wordt aangepast aan individuele plaatselijke situaties en eisen van de klant, en leidt tot aanzienlijke besparingen.
Hygienic pumps
GEA Hilge biedt een veelzijdige serie centrifugaal- en verdringingpompen voor vele verschillende gevoelige toepassingen in de dranken-, levensmiddelen- en farmaceutische industrieën.
Kleppen & onderdelen voor aseptische vloeistofverwerking
Aan aseptische kleppen worden zeer hoge eisen gesteld binnen UltraClean- en aseptische processen. U kunt er zeker van zijn dat ze allemaal de hoogste kwaliteit bieden als het gaat om hygiënisch ontwerp en duurzaamheid.
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GEA-inzichten
Pre2Fuel: Cleared for takeoff
GEA's innovative process marks a milestone in the pretreatment of biofuels such as hydro-treated vegetable oil and sustainable aviation fuel. By eliminating the bleaching process, manufacturers benefit from significant savings potential: over 50% lower operating costs and up to 12% less CO2 emissions.
Het volgende tijdperk van voedselproductie met GEA NEXUS
Klimaatverandering en een groeiende wereldbevolking zetten de energie-intensieve voedselindustrie onder toenemende druk om meer mensen te voeden zonder de planeet verder te belasten. George Shepherd, GEA's Global Technical Sustainability Manager, legt uit hoe GEA zijn technische knowhow gebruikt om verwerkers te helpen duurzamer te produceren en tegelijkertijd de productiviteit te verhogen.
Making milk production more sustainable for a growing world
The world's population is growing and with it demand for milk. Dairy is an essential component of many global diets. However, its production can be resource-intensive and impact the environment. GEA’s Christian Müller, Senior Director Sustainability Farm Technologies, sheds light on how technological innovations powered by GEA make milk production more efficient and profitable.
