Liquid Dosage
Inhalable Suspension
Inhalation is often the preferred drug delivery method for lung diseases, offering a number of advantages for both patients and medical professionals for the administration of vaccines and other biological drugs.
The active ingredient of many inhalable products, such as anti-asthma medications, acts on the muscle cells of the pulmonary airways. Such medications can be rendered inefficient, however, if particles aggregate in the inhaler. In addition, to prevent dry powder aerosols from depositing particulate matter in the oropharyngeal cavity — and in the inhaler — dispensed particles should have a geometric diameter of 1–3 µm and a mass density of approximately 1 g/cm3.
Inhaled drugs are usually dissolved in an aqueous system, such as an isotonic salt solution, and aerosolized at a high pressure to obtain nebulized particles. The liquid solution is pumped through a homogenizing valve at 500–1000 bar, using a single stage process, during which semi-solid particles become dispersed in the liquid.
The high-pressure homogenization enables the size reduction of average to large particles and makes the suspension more stable as a result of the decreased sedimentation rate. Moreover, it eliminates biological risk and provides better tolerance to irritants, as well as improving the clarity and transparency of the processed product.
In addition to a comprehensive range of homogenizers, GEA also offers production-scale mixing, blending, spray drying and micronization solutions for the manufacture of inhalable products, plus an unparalleled level of expertise in the design and layout of suitable plant: from vessel size dimensions to valves and 3D P&IDs, and from R&D to full-scale production.
Producten & technologieën
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Analytische, in-line besturings- & meetapparatuur
Door procesbewaking met behulp van online analysesystemen te combineren met vaste principes van procesengineering en geavanceerde procesmodelleringstechnieken, kunnen processen actief bestuurd worden om invoervariaties te compenseren.
Aseptic valves & components
Aseptic valves face exceptionally high demands within UltraClean and Aseptic processes. You can be assured that they all provide highest quality in terms of hygienic design and sustainability.
Centrifugaalseparator
Separatoren van GEA zijn ontworpen voor toepassingen met vloeistof. Met behulp van centrifugaalkracht kunnen ze worden gebruikt voor het scheiden van suspensies die twee of meer fasen met verschillende dichtheden bevatten; dat wil zeggen dat ze gebruikt kunnen worden voor vloeistof-vloeistof-scheiding, vloeistof-vloeistof-vastestof-scheiding of v...
CIP/SIP-oplossingen
Innovatieve CIP-concepten van GEA voldoen aan hoge normeringen. Onze experts garanderen productveiligheid in elke fase van het proces. Elke upgrade wordt aangepast aan individuele plaatselijke situaties en eisen van de klant, en leidt tot aanzienlijke besparingen.
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Modern herd management: a smarter way to farm
In a dairy herd, every cow has her own story – and modern herd management tools help tell it. By tracking health, habits and needs, these smart systems let farmers care better, work smarter and keep milk flowing. It's the secret behind happy herds and successful, more sustainable dairy farming.
De toekomst voeden: de kracht van vriesdrooginnovaties
Afvalreductie is belangrijk voor ons bij GEA en door de kracht van vriesdroogtechnologie te benutten, kunnen we voedseloverschotten omzetten in waardevolle, duurzame producten die ons helpen afval te reduceren, de houdbaarheid te verlengen en een beter bestendige voedselvoorzieningsketen voor toekomstige generaties te creëren.
