Liquid Dosage
Insulin
With diabetes on the rise and the global insulin market estimated to be worth more than $32 billion by 2018, demand for GEA technologies for the production of this life-saving drug is already high and set to increase, particularly in new markets and emerging economies.
State-of-the-Art Solutions
GEA produces and supplies process systems for the production of liquid products for the pharmaceutical and biotechnological industries, and has a proven history of successfully installing plant for the production of insulin, including the engineering, delivery, commissioning and qualification of entire ultra-pure media systems as well as various process equipment and cleaning installations.
A worldwide technology leader in insulin production, GEA is able to supply the clean utility systems and manage the integration of all the main processes, including fermentation, harvesting, chromatography, filtration and freeze drying.
From Fermentation to Freeze Drying
The biosynthetic production of human insulin is done using bacteria or yeast cells. Following fermentation, or the conversion of chemical raw materials by micro-organisms, the biomass is extracted using a nozzle separator, washed, concentrated and finally precipitated to produce insulin crystals.
Centrifuges and process lines provided by GEA have an established pedigree in the clarification, separation, classification, concentration and fractionation steps. Nozzle separators also play an important part in the production process. Further, GEA chamber or self-cleaning separators can be used in the subsequent crystallization stages.
GEA is a single-source supplier of a variety of fermenters, media preparation, buffer storage, harvesting and cell rupture solutions, equipment for the purification and isolation of cells, separation (after both first and final crystallization), the production and distribution of WFI, CIP and freeze drying technologies, all of which can be installed and integrated into a state-of-the-art insulin production facility.
Producten & technologieën
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Afsluitkleppen
Aseptische afsluitkleppen met enkele zitting worden gebruikt voor het gecontroleerd openen en sluiten van pijplijnen in UltraClean- en aseptische verwerkingsinstallaties.
Analytische, in-line besturings- & meetapparatuur
Door procesbewaking met behulp van online analysesystemen te combineren met vaste principes van procesengineering en geavanceerde procesmodelleringstechnieken, kunnen processen actief bestuurd worden om invoervariaties te compenseren.
Aseptisch piggingsysteem
Met een aseptisch piggingsysteem kunnen waardevolle producten uit de productleiding worden teruggewonnen. Aangedreven door steriel water of perslucht duwt de 'pig' het product uit de leiding. De achterblijvende productresten aan de binnenkant van de productleiding kan vervolgens via CIP worden verwijderd.
Bemonsteringskleppen
Aseptische bemonsteringskleppen worden gebruikt voor veilige monstername in UltraClean- en aseptische verwerkingsinstallaties
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